Reduced neurite density in the brain and cervical spinal cord in relapsing–remitting multiple sclerosis: A NODDI study

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Application and evaluation of NODDI in the cervical spinal cord of multiple sclerosis patients

INTRODUCTION There is a need to develop imaging methods sensitive to axonal injury in multiple sclerosis (MS), given the prominent impact of axonal pathology on disability and outcome. Advanced multi-compartmental diffusion models offer novel indices sensitive to white matter microstructure. One such model, neurite orientation dispersion and density imaging (NODDI), is sensitive to neurite morp...

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ژورنال

عنوان ژورنال: Multiple Sclerosis Journal

سال: 2019

ISSN: 1352-4585,1477-0970

DOI: 10.1177/1352458519885107